The Role of PARP Activation in Prostate Cancer
نویسنده
چکیده
Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer related mortality. Localized prostate cancer is treated by either radical pros‐ tatectomy or radiotherapy. Low levels of testosterone have been associated with prostate cancer progression. These tumor presented advanced tumor stage, high Gleason scores, and had significantly worse overall survival rate [1, 2]. Indeed, intraprostatic dihydrotestoster‐ one (DHT) were consistently reduced in patients with high-grade (Gleason scores of 7 to 10) compared to patients diagnosed with low grade tumors (Gleason scores of 6 or less) [3]. Prostate cancer usually is treated using chemotherapy, radiotherapy, or surgery. For ad‐ vanced prostate cancer, hormonal therapy is currently used as the standard treatment, how‐ ever; these tumors develop and aggressive phenotype and become hormone–independent (hormone-refractory) (HRPC) that is resistant to chemotherapy or radiotherapy and meta‐ stasizes to lymph nodes and bone [4].
منابع مشابه
Novel Poly(Adenosine Diphosphate-Ribose) Polymerase (PARP) Inhibitor, AZD2461, Down-Regulates VEGF and Induces Apoptosis in Prostate Cancer Cells
Background: Prostate cancer (Pca) is a heterogeneous disease, and current treatments are not based on molecular stratification. Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors have recently been found to be remarkably toxic to cells with defects in homologous recombination, particularly cells with BRCA-mutated backgrounds. Therefore, this preliminary study was designed to ...
متن کاملThe Role of Adiponectin in Prostate Cancer: A Narrative Review
Prostate cancer (PCa) is the most common type of cancer among men over 60 years old. The aggressiveness and mortality of PCa can be correlated with obesity. Adipose tissue-derived cytokines such as adiponectin may explain the correlation between PCa and obesity. Since the correlation between adiponectin and aggressive PCa is still not fully evaluated, we aimed to investigate the probable role o...
متن کاملThe Roles of Long non-coding RNAs (lncRNA) in Prostate Cancer
Background & Objective: Prostate cancer is a compound condition in which gene expression has altered. Several surveys have revealed that genetic components have been involved in prostate cancer progression. Findings proposed that they can modify a noteworthy portion of disposing of elements, which is associated to the developing prostate cancer in protein coding sequences. The purpose of this r...
متن کاملDiagnostic uncertainty of isolated skull lesion in prostate cancer- Role of SPECT/CT
Skeletal involvement is the second most common site of metastases after lymph nodal metastases in patients with prostate cancer. The skeletal metastases from prostate cancer are osteoblastic in nature and show increased tracer avidity on the bone scan. Focal tracer avid lesion in skeleton especially in skull requires the careful examination by further investigation. The patients with skull meta...
متن کاملPoly (ADP-ribose) Polymerase 1 Protein Expression in Normal and Neoplastic Prostatic Tissue
A genetic background has been implicated in the development of prostate cancer. Protein microarrays have enabled the identification of proteins, some of which associated with apoptosis, that may play a role in the development of such a tumor. Inhibition of apoptosis is a co-factor that contributes to the onset and progression of prostate cancer, though the molecular mechanisms are not entirely ...
متن کاملInfluence of estrogen and polyamines on mifepristone-induced apoptosis in prostate cancer cells.
PURPOSE Although androgens are the main steroids controlling the growth of prostate glands, estrogens are also important in the regulation of its growth. Prostate cancer cells, like other cancer cells, maintain high levels of polyamines. In LNCaP cells, apoptosis is induced by mifepristone. During the process of cell death, the regulation of ROS production, caspase-3 activation and poly (ADP-ri...
متن کامل